7-Aminobutyric acid dependent chloride

In addition to a-allenic a-amino acids, the corresponding allenic derivatives of y-aminobutyric acid (GABA) have also been synthesized as potential inhibitors of the pyridoxal phosphate-dependent enzyme GABA-aminotransferase (Scheme 18.49) [131,138-142]. The synthesis of y-allenyl-GABA (152) and its methylated derivatives was accomplished through Crabbe reaction [131], aza-Cope rearrangement [138] and lactam allenylation [139], whereas the fluoroallene 153 was prepared by SN2 -reduc-tion of a propargylic chloride [141]. 

Albrecht J, Norenberg MD. 1991. Aluminum chloride stimulates NACl-dependent release of taurine and aminobutyric acid in rat cortical astrocytes. Neurochem Int 18 125-129. 

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