7-Aminobenzo phenanthrolines

All other chemicals employed were of the highest grade available. 5-Nitro-l,10-phenanthroline, 5-amino-l,10-phenanthroline [6] and benzo[15-crown-5], 15-nitrobenzo[15-crown-5], 15-aminobenzo[15-crown-5] were prepared according to the published methods [7, 8],... 

Wardani and Lhomme (93TL6411) reported two routes for the synthesis of 10-aminobenzo[h][l,7]phenanthroline 64 from 3,6-diaminoacridine (proflavine) 58. In first route the proflavine 58 was monoacylated to give 59. Activation of the free amino group was achieved by tosylation. Alkylation of the monoacetyl monotosyl proflavine 60 with 3-bromopropionaldehyde ethylene acetal gave the intermediate 61. Acidic treatment afforded 10-aminobenzo[h][l,7]phenanthroline 64 in an 18% overall yield starting from... 

The synthesis of a number of benzo[b][l,7]phenanthroline anticancer agents from 10-aminobenzo[b][l,7]phenanothroline 64 has been claimed (91MIP1). Thus, ll-formyl-10-hydroxybenzo[h][l,7]phenanthroline 66 exhibited cytotoxicity, with an IC50 of 6.5 fiM, against L1210 leukemia cells. 

---