3-Amino-2,6,6-trimethylbicyclo heptan

Preparative Methods optically pure (l/ ,2/f,35,5R)-3-amino-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol (ATBH) can be prepared from optically impure (l/ ,55)-a-pinene (eq 1). Oxidation of (lR,55)-a-pinene (81% ee) with potassium permanganate and subsequent reaction with hy-droxylamine affords the a-hydroxy oxime, which is re-... 

Amino-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol 38 Merck Research Laboratories, Rahway, NJ, USA... 

R)-2-endof-endo-3-Amino-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol (11) (91 %) is isolated from (1 ft)-cWo-3-amino-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one (10) with isobutylaluminum dichloride (prepared from triisobutyl aluminum and aluminum trichloride)196. 

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