Amino sugars Knoevenagel reaction

One of the most versatile domino reactions involving a cycloaddition step is the domino Knoevenagel/hetero Diels-Alder reaction, which was developed by Tietze et al. It has been used for the efficient synthesis of innumerous heterocycles and many natural products. A novel example is the preparation of the amino sugar D-forosamin by Tietze et al. using a three-component reaction, which is described in detail in Chapter 14 [60]. 

L. F. Tietze, S. Dietz, N. Bohnke, M. A. Diifert, I. Objartel, D. Stalke, Eur. J. Org. Chem. 2011, 6574-6580. Three-component domino Knoevenagel/hetero-Diels-Alder reaction for the synthesis of the amino sugars 2-acetoxyforosamine and 2-acetoxyossamine—experimental and theoretical results. 

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