Amino-steroids and Steroidal Alkaloids

Considerable difficulties had to be overcome in the isolation of four major highly cardiotoxic steroidal alkaloids from the skin secretions of the Colombian arrow-poison frog Phyllobates aurotaenia. The very labile pseudobatrachotoxin, whose 

Shimizu, Y. Sato, and H. Mitsuhashi, Ghent, and Pharm. Bull. Japan), 1969, 17, 2391. 

The proposed structure (486) of solanocapsine has been confirmed by JV-ray analysis of its iV-(2-bromobenzylidene) derivative and by the synthesis 

Cyclobuxine D has been converted into cyclobuxosuffrine (493) thereby confirming the structure of that compound. 

---