Amino-5-nitropyrimidine

The checkers found the product to be quite pure. An almost quantitative yield of 2-amino-5-nitropyrimidine was obtained by reaction of the product with guanidine. 

Amino-5-nitroanisole, 37, 4 2-Amino-5-nitropyrimidine, 32, 96 2-Amino-3-nitrotoluene, 36, 3 2-Amino-5-nitrotoluene, 36, 5... 

We have been unsuccessful in preparing this 1 1 cocrystal of 2,5-diaminopyrimidine and 2-amino-5-nitropyrimidine from solution but we have prepared a 1 1 cocrystal of the two components by solid-state grinding and heating. Neither the crystal structure nor the hydrogen-bond pattern is known at this point, but the X-ray powder pattern of the cocrystal product is distinctly different from those of the starting materials. 

Amino-5-nitropyrimidine, cocrystallization, 455 Amorphous polymers, criteria for use in second harmonic generation, 250-251 Amphiphilic molecules polar Z-type Langmuir-Blodgett films, formation, 473-479 structures, transfer behavior, and contact angles, 474,476-477r Anharmonic oscillator models, nonlinear optical effect-microstructure relationship, 361... 

Guanidine reacts with nitromalonaldehyde in nearly quantitative yield to produce 2-amino-5-nitropyrimidine (116 R = NH2).106 107 111 N,N-Dimethylguanidine reacts similarly to produce the 2-dimethylamino compound (116 R = NMe2) in 33% yield.112 The reaction has been applied to a complex guanidine related to lysergic acid.113... 

P Politzer, G. P. Kirschenheuter, and R. S. Miller,/. Phys. Chem., 92,1436 (1988). Computational Study of 2-Aminopyrimidine, 2-Amino-5-nitropyrimidine, and the Corresponding S,S-Dimethyl-N-sulfilimines. 

Amino-5-nitropyrimidine has only a moderate degree of anticoccidial activity at slightly toxic concentrations in the chicken (015 per cent). The... 

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