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Amino interactions with free

In earlier studies the in vitro transition metal-catalyzed oxidation of proteins and the interaction of proteins with free radicals have been studied. In 1983, Levine [1] showed that the oxidative inactivation of enzymes and the oxidative modification of proteins resulted in the formation of protein carbonyl derivatives. These derivatives easily react with dinitrophenyl-hydrazine (DNPH) to form protein hydrazones, which were used for the detection of protein carbonyl content. Using this method and spin-trapping with PBN, it has been demonstrated [2,3] that protein oxidation and inactivation of glutamine synthetase (a key enzyme in the regulation of amino acid metabolism and the brain L-glutamate and y-aminobutyric acid levels) were sharply enhanced during ischemia- and reperfusion-induced injury in gerbil brain. [Pg.823]

See other pages where Amino interactions with free is mentioned: [Pg.5]    [Pg.106]    [Pg.201]    [Pg.260]    [Pg.209]    [Pg.449]    [Pg.449]    [Pg.551]    [Pg.47]    [Pg.4]    [Pg.175]    [Pg.467]    [Pg.85]    [Pg.157]    [Pg.588]    [Pg.602]    [Pg.211]    [Pg.301]    [Pg.439]    [Pg.482]    [Pg.25]    [Pg.187]    [Pg.4]    [Pg.89]    [Pg.98]    [Pg.347]    [Pg.349]    [Pg.855]    [Pg.39]    [Pg.286]    [Pg.303]    [Pg.40]    [Pg.218]    [Pg.15]    [Pg.148]    [Pg.66]    [Pg.149]    [Pg.328]    [Pg.162]    [Pg.165]    [Pg.188]    [Pg.102]    [Pg.451]    [Pg.481]    [Pg.252]    [Pg.815]    [Pg.88]    [Pg.127]    [Pg.291]   
See also in sourсe #XX -- [ Pg.449 ]



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