2-Amino-3-cyanopyrazine 1,4-dioxide

Amino-3-cyanopyrazine 1,4-dioxide was selectively monodeoxygenated with phosphorus trichloride in tetrahydrofuran at 25° to 3-amino-2-cyanopyrazine 1 -oxide (538). 

Diisobutyl-3miethoxypyrazine 1,4-dioxide (107) with phosphorus trichloride in ethyl acetate at 40° gave 2,5-diisobutyl-3-methoxypyrazine (980). 2-Amino-5-[(/7-chlorophenoxy)methyl]-3-cyanopyrazine 1-oxide was deoxygenated with triethyl phosphite in dimethylformamide at 120° (1041). 

The oxidations of 2-amino-3-cyanopyrazine 1-oxides to the 1,4-dioxides are described in Section VIII.3A(4) and deoxygenations of some 2-amino-3-cyano-pyrazine 1-oxides and 1,4-dioxides with phosphorus trichloride or sodium dithionite in Section VIII.3C(4). Deoxygenation and chlorination of aminocyanopyrazine 1-oxides are reported in Section V.IG, and deoxygenation and acetoxylation or alkoxylation of 2-amino-3-cyano-5-methylpyrazine 1,4-dioxide in Section VIII.3C(5). Hydrolysis of cyanopyrazine Y-oxides to carbamoylpyrazine Af-oxides are given in Section 10A(3) and ring closure reactions of 2-amino-3-cyanopyrazine 1-oxides to pteridine 8-oxides in Section V11I.3C(3). 

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