2-Amino-3-carbamoyl-5-chloropyrazine

Acylaminopyrazines have been deacylated by hydrolysis in acid, or alkali, by methanolysis, or by hydrazinolysis (in propan-2-ol) under a variety of conditions to give the corresponding amino compound unless otherwise specified in the following examples 2-acetamido-3-acetoxymethylpyrazine (28) (dilute acetic acid at reflux for 6h) (1075) 2-acetamido-5-chloro-3-amidinocarbamoylpyrazine (5% hydrochloric acid-acetic acid at 100°) (150) 2-acetamido-3-A(-(benzimidoyl)-carbamoyl-5-chloropyrazine (5% hydrochloric acid at room temperature) (150) ... 

Carbamoyl-3-hydroxypyrazine refluxed with aniline gave 2-hydroxy-3-7V-phenylcarbamoylpyrazine (1055) and 2-amino-3-carbamoyl-5,6-diphenylpyrazine refluxed with benzylamine gave 2-amino-3-A -benzylcarbamoyl-5,6-diphenylpyrazine but a similar reaction with piperidine was unsuccessful (451). 3-Methylamino-2-yV-methylcarbamoyl-5-phenylpyrazine was unchanged when heated with liquid ammonia in dry ethanol at 210° for 2 hours (453). 2,6-Diamino-3-carbamoyl-5-chloropyrazine in isopropanol with 1 mol of potassium hydroxide and 1 -amidino-... 

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