Amines through Hofmann rearrangement

Carboxylic acid derivatives can be converted into primary amines with loss of one carbon atom by both the Hofmann rearrangement and tire Curtius rearrangement. Although the Hofmann rearrangement involves a primary-amide and the Curtius rearrangement involves an acyl azide, both proceed through similar mechanisms. 

Another reaction that can be used for conversion of carboxylic acids to the corresponding amines with loss of carbon dioxide is the Hofmann rearrangement. The classic reagent is hypobromite ion, which reacts to form an A-bromoamide intermediate. Like the Curtius reaction, this rearrangement is believed to be a concerted process and proceeds through an isocyanate intermediate. 

E Preparation of Primary Amines through the Hofmann and Curtius Rearrangements... 

Hofmann Rearrangement Amides with no substituent on the nitrogen react with solutions of bromine or chlorine in sodium hydroxide to yield amines through loss of their carbonyl carbon by a reaction known as the Hofmann rearrangement or Hofmann degradation-. 

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