Amines solid support catalysts, arylation

Solid-supported versions of the Buchwald-Hartwig reaction are known too. In 2012, Al-Amin et al. [42] reported a stable heterogeneous sulfur-modified gold-supported palladium material (SAPd), which was used for the amination of aryl bromides and chlorides. The catalyst was employed at a loading of about 0.2 mol%, and can be used for a minimum of 10 reaction cycles without loss of catalytic activity, affording very good yields for a large cross-section of substrates. 

As an extension to a biphasic system reported previously, de Mello and coworkers [77] described the incorporation of a silica-supported Pd catalyst into a fluidic system and investigated the gas-solid-liquid carbonylation reaction of an aryl halide (24), an amine (134) and carbon monoxide (Scheme 6.33), to afford the respective N-benzylbenzamide (135). To conduct the reaction, a solution of aryl halide and amine, in THF, was pumped through the reactor at a flow rate of 10 pi min-1, where it was mixed with CO (2 seem) in a T-mixer, prior to passing through the packed-bed reactor [1 mm i.d. x 45 cm (length)]. Maintaining the system at 75 °C,... 

---