Amine-mediated epoxidation system

Another amine-mediated epoxidation system, discovered by the group of Jorgensen, consists of proline-derived catalysts and is mechanistically distinct... 

Recently, two other groups have shown that exocyclic iminium salts can be useful mediators in asymmetric epoxidation. Komatsu has developed a system based on ketiminium salts [14], prepared through the condensation of aliphatic cyclic amines with ketones. A chiral variant was also produced, derived from prolinol and cyclohexanone, which gave 70% yield and 39% ee for cinnamyl alcohol (Scheme 5.7). 

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