Amine Claisen-Schmidt reaction

Although the reduction of nitro compounds is more widely applied in the aromatic series using procedures discussed in Section 6.5.1, p. 890, these are equally applicable to the reduction of primary or secondary nitroalkanes when these are readily available. a,/ -Unsaturated nitro compounds (arising for example from the Claisen-Schmidt reaction, Section 6.12.2, p. 1032) may be reduced to the saturated amine very effectively with sodium dihydrobis(2-methoxyethoxy)-aluminate ( Red-Al ). 

Claisen head adapter, 20, 26,134 Claisen-Schmidt reaction, 309-317 classification tests, 640-654. See also qualitative analysis alcohols, 640-642 aldehydes, 642-644 alkanes, 644-645 alkenes, 645 alkyl halides, 645-646 aUcynes, 645 amides, 647-648 amines, 648-649 ammonium salts, 647-648 aromatic hydrocarbons, 649-650 carboxylic acids, 650 cycloalkanes, 644-645 defined, 630 enols, 653-654 esters, 650-651 ethers, 651... 

Besides the aldol reaction to form y0-hydroxyketone, 1,3-Dipolar Cycloaddition can also form similar molecules. In addition to the Mukaiyama Aldol Reaction, the following are also similar or closely related to the aldol reaction the Claisen-Schmidt Condensation (the aldol reaction between benzaldehyde and an aliphatic aldehyde or ketone in the presence of relatively strong bases to form an o, )0-unsaturated aldehyde or ketone), the Henry Reaction (base-catalyzed addition of nitroalkane to aldehydes or ketones), the Ivanov Reaction (the addition of enediolates or aryl acetic acid to electrophiles, especially carbonyl compounds), the Knoevenagel Reaction (the condensation of aldehydes or ketones with acidic methylene compounds in the presence of amine or ammonia), the Reformatsky Reaction (the condensation of aldehydes or ketones with organozinc derivatives of of-halo-esters), and the Robinson Annulation Reaction (the condensation of ketone cyclohexanone with methyl vinyl ketone or its equivalent to form bicyclic compounds). 

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