Amikacin vestibular function

Sensory systems Vestibular function Measurement of vestibular function in infants who had received amikacin, using vestibular evoked myogenic potentials in 28 infants and healthy controls, showed that the vestibular organ was damaged by amikacin more often than the cochlea (6 versus 0 abnormal findings) [6 ]. 

Amikacin/ kanamycin Adults See footnote8 Children 15-30 mg/kg per day intravenous or intramuscular as a single daily dose Ototoxicity, nephrotoxicity Baseline audiogram, vestibular testing, Romber testing and SCr Monthly assessments of renal function and auditory or vestibular symptoms... 

The same spectrum of toxicity (ototoxicity and nephrotoxicity) is shared by all members of the group, The more important and frequent interactions are pharmacodynamic. Streptomycin and gentamicin produce predominantly vestibular effects, whereas amikacin, kanamycin and neomycin primarily affect auditory function. All are rapidly excreted by the kidney,... 

---