Indometacin Amikacin

INDOMETACIN AMINOGLYCOSIDES T amikacin, gentamicin, and vancomycin levels in neonates Uncertain indometacin possibly 1 renal clearance of these aminoglycosides Halve the dose of antibiotic. Uncertain whether this applies to adults but suggest check levels. Otherwise use an alternative NSAID... 

There are conflicting reports as to whether or not serum gentamicin and amikacin ieveis are raised by indometacin or ibupro-fen in premature infants. 

A study in 10 preterm infants with gestational ages ranging from 25 to 34 weeks, who were given amikacin, found that the use of indometacin 200 mierograms/kg every 8 hours, for up to 3 doses, caused a rise in the serum levels of amikacin. Trough and peak levels of amikacin were raised by 28% and 17%, respectively. ... 

In contrast, another study in preterm infants given amikacin found no changes in its pharmacokinetics when ibuprofen or indometacin were given. ... 

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