Amikacin amine

N-ethyl kanamycin A (153) has some resistance to APH(3 ), ANT(2 ), and AAC(3). Butakacin [59733-86-7] C22H N 0 2 t i l-A/-(3)-2-hydroxy-4-aminobutyl derivative of kanamycin A (154), has antimicrobial properties similar to amikacin. A similar effect was seen with the l-A/-(l,3-dihydroxy-2-propyl) derivative of kanamycin B, propikacin [66887-96-5] C22H42N 022 (155). Methylation of the 6 -amine reduces susceptibility to AAC(6 ) (156). 

Other examples of general base catalysis and nucleophilic catalysis that have been reported include the hydrolysis of cefotiam388 and cefsulodin166 catalyzed by amikacin and kanamycin and the hydrolysis of moxalactam389 catalyzed by various amines. 

Nitrobenzenes are most commonly used for the derivatization of amino compounds. The 4-nitrobenzoyl group has been shown to impart high UV absorptivity to amines. l-Fluoro-2,4-dinitrobenzene has been used as a label for aminoglycosides (Figure 5) such as neomycin [25, 26], fortimicin A [27], amikacin [28, 29], tobramycin [30-33], gentamicin and sissomicin [31-33]. 

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