Amidocuprates chiral

Intramolecular hydroamination of A -benzenesulfonyl-4-alkenylamine and analogues is catalyzed by Cu(OTf)2. Oxidative cyclization involving the benzene ring is promoted by Mn02 that is added. When a chiral BOX ligand (ent-lB) is present amidocuprate species are formed prior to hydroamination and the transition state is regulated. 

Conjugate Addition Reactions. - Two protocols for achieving the enantioselective conjugate addition of an alkyl group to an enone using a cuprate containing a chiral ligand have been reported. In one case the lithium amide (28) was used to prepare an amidocuprate... 

Chiral amidocuprates have also been demonstrated to function as catalysts in asymmetric conjugate additions for selected substrates [43], A seminal result was disclosed by Lippard, who used amidocuprate 170 (Equation 30) [135]. This complex is generated from the deprotonated aminotropone... 

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