Amido groups, determination

Because the reductive elimination from DPPF-ligated palladium does not involve geometric rearrangements or changes in coordination number before the rate-determining step, the DPPF complexes allowed an assessment to be made of the electronic properties of the transition state in this reaction. The relative rates for elimination from amido groups were found... 

From this equation it is evident that by reduction, the amine which was diazotised—in the above case sulphanilic add—may be obtained again on the one hand, on the other an amido-group is introduced into the second component. If the constitution of this second product can be determined, then the constitution of the azo dyes is also determined. It may be stated as a general rule that, when a diazo-compound combines with an amine or phenol, the hydrogen atom in the para position to the amido- or hydroxyl-group is always substituted. In accordance with this, in the above case, p-amidodimethyl aniline ought to be obtained on reduction. If the para position is already occupied, then, the o-hydrogen atom Mites With the acid radical-... 

The amido group is determined by hydrolysis, in a similar manner to the nitrile group (preceding section). 

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