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Amidines carboxylic acid thioamide

Via intermediates Amidines from nitriles via carboxylic acid thioamides and thioiminoester salts... [Pg.352]

With primary and secondary amines, the aminolysis of a trifluoromethyl group to a carbonitrile group is not possible nevertheless, under these reaction conditions, analogs of carboxylic acids, c.g. amidines,51,52 amides29,53 - 55 or thioamides,56 are formed. [Pg.451]

A few 6- and 8-cyanopurines have been prepared and undergo characteristic nitrile addition reactions rather readily. Thus, alkaline hydrolysis produces carboxamides, then carboxylic acids, alcoholysis leads to imidates, ammonolysis to amidines, hydrazinolysis to amidhydrazines, hydroxylamine to amidoximes, and hydrogen sulfide to thioamides. Acid hydrolysis tends to give the decarboxylated acid derivative. Reduction either by sodium-ethanol or, preferably, by catalytic hydrogenation affords aminoalkylpurines and addition of Grignard reagents produces, in the first place, acylpurines. As with aldehydes, most of the compounds examined have been relatively non-polar derivatives. Table 28 lists some reactions and relevant literature. [Pg.548]

Tetrakis(dimethylamino)titanium is a useful reagent for preparing amidines from secondary amides. From A X-thionyldiimidazole and secondary amides of boA aromatic and aliphatic carboxylic acids amidines (313 Scheme 50) are formed under mild conditions in moderate to good yields. N-Tosyl-amidines (314) can be obtained by reacting secondary thioamides (aliphatic and aromatic) with tosyl azide. Thiobenzamides have been condensed with anilines to afford amidines (315). Thioamides can be converted to amidines, e.g. (316), by treatment with ammonia in the presence of mercury acetate. ... [Pg.546]

In most cases these C,N2 fragments are prepared by reaction of activated carboxylic acid derivatives (C, fragment), such as dithiocarboxylates 2, thioesters 3. nitriles 5, imidates 6, amidines 7, thioamides 8, selenoamides 9, selenoesters 11, orthocarboxylates 14, with hydrazine (N2 fragment) and are transformed to l,4-dihydro-l,2,4,5-tetrazines 17 without isolation. Therefore, these syntheses are treated as a (2 + 1 +2+1) fragment method. [Pg.884]


See other pages where Amidines carboxylic acid thioamide is mentioned: [Pg.166]    [Pg.240]    [Pg.569]    [Pg.569]    [Pg.469]    [Pg.469]   
See also in sourсe #XX -- [ Pg.13 , Pg.604 ]




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Amidinate

Amidinates

Amidination

Amidines

Amidines acids

Amidins

Carboxylic acid thioamides amidines

Thioamidation

Thioamide

Thioamides

Thioamides acidity

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