Amides titanium chloride-magnesium

ARCTON (75-46-7) Violent reaction with alkaline earth and alkali metals. Reacts violently with aluminum oxide at elevated temperatures, producing hydrogen chloride and phosgene vapors. Incompatible with beryllium, decaborane, diborane, difluoromethylene dihypofluorite, fluorine, lithium, magnesium, potassium, potassium acetylene-1,2-dioxide, potassium acetylene-1,2-dioxide, potassium sodium alloy, sodium amide, titanium, uranium hydride, zinc. Attacks aluminum, magnesium, zinc, and their alloys. 

A one-pot procedure for the preparation of 1,2-diamines 161 (NR 2 = NMe2, NEt2 or piperidin-l-yl R = Ph, Ar or 2-furyl) has been described the lithinm amide LiNR 2 is added to an aldehyde R CHO and the mixture is treated successively with an equivalent of titanium(IV) chloride and a low-valent titanium reagent prepared by redncing titanium(IV) chloride with magnesium. The products are obtained in 23-81% yields as mixtures of DL- and meso-isomers . 

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