Amides oxamide formation

Oxamides, dialkyl oxalate esters, and oxamic add esters can be prepared by Pd-catalyzed double carbonylation of secondary amines and alcohols via incorporation of two molecules of carbon monoxide into amines and/or alcohols. Pd-catalyzed double carbonylation reactions of amines in the absence or presence of alcohol were reported earlier to give ox-amides and oxamic acid ester.t i t Selective formation of oxamides has been achieved by double carbonylation of secondary amines in the presence of iodide ion and dioxygen catalyzed by Pd(OAc>2 (Eq. 

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