Amides amidine synthesis

The direct synthesis of aryl- or alkyl nitriles from cyanide and organohalide precursors is revered in synthetic chemistry, as the nitriles represent a flexible functionality that can easily be converted into (for example) carboxylic acids, esters, amides, amidines, amines and various hetero cycles [67], such as thiazoles, oxazolidones, triazoles and tetrazoles [68]. The tetrazole group... 

Thioamides are used as more reactive precursors than amides for amidine synthesis. Lawesson reagent is normally used for conversion of amide to thioamide. Preparation of an amidine-type mannosidase inhibitor 6 is shown as a representative example [14] (Scheme 3.13). 

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