Amide—Continual

Reactivity Chart 9. Protection for the Amino Group Amides (Continued)... 

Amide—Continued from an acid and urea, 25, 95 preparation by ammonolysis, 20, 62 Animation, by reduction of a ketone in the presence of ammonia, 23, 68 of bromoacetal with use of high-pressure hydrogenation bomb, 24, 3 of a-bromoisocaproic acid, 21, 75 of a-bromo-/3-methylvaleric acid, 21, 62... 

As in recent years, the synthesis of new chiral phosphines and related chiral tervalent phosphorus esters and amides continues to be a major preoccupation, being driven by the need for improved performance in metal-catalysed processes. It is very pleasing to note that two of the recipients of the 2001 Nobel Prize for Chemistry, William S. Knowles, and Ryoji Noyori, are honoured for their work in the synthesis and application in catalysis of chiral phosphine ligands. Interest in the structures of metallo-organophosphide systems, noted in the previous volume, has continued to develop. The chemistry of heteroaromatic ring systems, notably that of phospholes, and of low coordination number p -bonded compounds, also remain active areas. 

Simple amides continue to be isolated from the Piperaceae fcunily N-trans-feruloylpiperidine, feruperine (14), and its 4,5-dihydro-derivative have been isolated for the first time from natural sources (Piper nigrum).Isopiperlonguminine (15 Z,Z R = H),... 

Prodtjcts and YibiiDS Obtained in Hofmann Reactions of Amides—Continued... 

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