Amidation alkenes

There are transition-metal catalyzed addition reaction of alkyl units to alkenes, often proceeding with metal hydride elimination to form an alkene. An intramolecular cyclization reaction of an A-pyrrolidino amide alkene was reported using an iridium catalyst for addition of the carbon ot to nitrogen to the alkene unit. OS I, 229 IV, 665 VII, 479. 

Also via Section 313 (Alcohol - Carboxylic Acid) Section 349 (Amide - Alkene)... 

The reactions of lipids represent many reactions that we have studied in previous chapters, especially reactions of carboxylic acids, alkenes, and alcohols. Ester hydrolysis (e.g., saponification) liberates fatty acids and glycerol from triacylg-lycerols. The carboxylic acid group of a fatty acid can be reduced, converted to an activated acyl derivative such as an acyl chloride, or converted to an ester or amide. Alkene functional groups... 

In the reactions of sulfanyl aldehydes with aUcenes in the presence of a rhodium catalyst, hydroacylation proceeds via an intramolecular five-membered ring intermediate with the insertion of an alkenyl moiety between the rhodium and carbonyl carbon at the y-position to the coordinating atom [112-114], For example, p-methylsulfanyl aldehyde reacts with an amide alkene to give an intermolecular hydroacylation product with the insertion of an amide alkenyl moiety at a high yield, as shown in Eq. (7.56) [112]. 

The CDC between A-f-butyl nitrones and terminal alkynes to form alkynylated nitrones in good to excellent yields, catalysed by zinc trifiate, was achieved using 3,3, 5,5 -tetra-tertbutyldipheno-quinone and O2 as oxidants. The alkynylated nitrones were transformed to regioisomerically pure 3,5-disubstituted isoxazoles. Experimental and DFT computational studies of Pd(OAc)2/pyridine-catalysed intramolecular aerobic oxidative amination of alkenes supported a stepwise mechanism that involved (i) the formation of a Pd(ll)-amidate-alkene chelate with release of 1 equiv. of pyridine and AcOH from the catalyst centre, (ii) insertion of alkene into a Pd—N bond. 

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