Phenylpropanolamine Amantadine

Amantadine and phenylpropanolamine may have caused intense recurrent deja vu experiences in a healthy 39-year-old within 24 hours of starting both drugs for influenza (13). 

Taiminen T, Jaaskelainen SK. Intense and recurrent deja vu experiences related to amantadine and phenylpropanolamine in a healthy male. J Clin Neurosci 2001 8(5) 460-2. 

The use of amantadine in a patient also taking phenylpropanolamine resulted in psychosis, and concurrent use in another patient resulted in intense and recurrent deja vu experiences. 

A case report describes the development of severe psychosis in a woman within 7 to 8 days of starting amantadine 100 mg [fiequency unclear but possibly twice daily] and phenylpropanolamine 80 mg daily. The reasons are not known, but both drugs alone, and in high doses sometimes cause psychosis, and concurrent use may enhance this effect. Another report describes intense and recurrent deja vu experiences in a 39-year-old man taking amantadine 100 mg twice daily and phenylpropanolamine 25 mg twice daily during a viral infection. These experiences stopped the day he discontinued the drugs. He had previously taken phenylpropanolamine without this effect. The authors considered the deja vu experiences to be related to increased dopamine activity caused by both drugs. ... 

Stroe AE, HaU J, AminF. Psychotic episode related to phenylpropanolamine and amantadine in a healthy female. Gen Hosp Psychiatry (1995) 17, 457-8. 

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