Alum-liposome formulations

A successful human trial of alum-adsorbed liposomes containing monophospho-ryl lipid A recently demonstrated that a formulation consisting of a combination of oil/water and adsorbent adjuvants can have considerable safety and efficacy and may be useful in the development of a potential vaccine against Plasmodium falciparum [29],... 

Liposomes are phospholipid vesicles that have been evaluated both as adjuvants and as vehicles for antigens and adjuvants (17). A liposomal hepatitis A (Hep A) vaccine (virosomes) has been extensively evaluated in the clinic and is currently licensed for a Hep A vaccine (18). Alternative adjuvants that have been used in a few products include L-tyrosine (allergy vaccine) and MPL (cancer treatment). The various adjuvants (mainly alum salts) used in vaccine formulations and their quantities per dose are listed in Table 1. 

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