Alprazolam, synthesis

Synthesis of the first two is described in Section 5.1 of Chapter 5. Benzodiazepines are described in the same place where the synthesis of structural analogs of midazolam (alprazolam, etc.) are described. 

Synthesis of 13C- and uC-labelled Alprazolam , Q-chloro-1 -(2-dimethylamino)-ethyl-6-phenyl-4H-S-triazolo [4,3-a] [1,4] benzodiazepine (178) and of its tosylate (178 los OH)... 

As a benzodiazepine-type drug, alprazolam is used to treat anxiety and panic disorders. The synthesis starts with a hydrazine benzodiazepine derivative followed by the imine formation, intramolecular cyclization, and oxidation to obtain alprazolam. ... 

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