Digoxin Alpha blockers

ALPHA-BLOCKERS CARDIAC GLYCOSIDES Possibility of T plasma concentrations of digoxin no cases of toxicity have been reported with doxazosin or prazosin Doxazosin inhibits P-gp-mediated elimination of digoxin mechanism with prazosin is uncertain at present Monitor digoxin levels... 

Caution is recommended when eplerenone is used with alpha blockers, antipsychotics, amifostine, baclofen, corticosteroids, tetracosactide and tricyclic antidepressants. Lithium, ciclosporin, and tacrolimus should generally not be used with eplerenone. Antacids, cisapride, midazolam and simvastatin had no effect on eplerenone pharmacokinetics. Eplerenone had no important effect on cisapride, midazolam, warfarin or contraceptive steroid pharmacokinetics, but caused a slight increase in digoxin levels. 

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