Allylation tris dipalladium

Fig. 1 Reaction scheme for the synthesis of the 2 -0-allyluridine building block Reagents i, l,3-dichlorO l,l,3,3-tetraisopropyldisiloxane in pyridine ii, chlorotri-methylsilane, and triethylamine in 1,2-dichloroethane, iii, 2-mesitylenesulfonyl chloride, triethylamine, and 4-dimethyIaminopyndine in dichloromethane iv, 2,6-dichlorophenol, l,4-diazabicyclo[2 2.2]octane and triethylamine v, p-toluene sulfonic acid monohydrate in THF/dichloromethane, vi, allyl ethyl carbonate, l,4-bis(diphenylphosphino)butane and tris(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran, vii, tetrabutylammonium fluoride in tetrahydrofuran viii, 2-nitro-benzaldoxime and 1,1,3,3-tetramethylguanidine in acetonitrile, ix, 4,4 -dimethoxytrityl chloride and triethylamine in pyridine x, 2-cyanoethoxy M -diisopropyl-aminochlorophosphine and //,iV-diisopropylethyiamine in 1,2-dichloroethane.

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