Allylation of acyloyl-imidazoles and pyrazoles

Allylation of acyloyl-imidazoles and pyrazoles with allyl halide mediated by indium in aqueous media provides a facile regioselective synthesis of P, y-unsaturated ketones (Scheme 11.1), which has been applied to the synthesis of the monoterpene artemesia ketone. The same product can be obtained by indium-mediated allylation of acyl cyanide (Eq. 11.35). Samarium, gallium, and bismuth can be used as a mediator for the allylation of nitrones and hydrazones to give homoallyhc hydroxylamine and hydrazides in aqueous media in the presence of Bu4NBr (Scheme 11.2). The reaction with gallium and bismuth can be increased dramatically under microwave activation. 

Allylation of acyloyl-imidazoles and pyrazoles with allyl hahde mediated by indium in aqueous media provides a facile regioselective synthesis of -imsaturated ketones. The re-... 

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