Alloxan diabetogenic activity

Alloxan (1003) has been observed in the mucus associated with dysentery and it was the very first pyrimidine made synthetically when Brugnatelli oxidized uric acid in 1818. Alloxan has an interesting diabetogenic action which appears to be associated with removal of essential zinc from insulin by chelation. Such permanent diabetes may be induced in fish, dogs, cats, sheep, some birds, monkeys and other creatures, but not in man, owls or guinea-pigs certain pyrimidines related to alloxan show some such activity. 

We detected also that the antioxidative enzymes activity in the pancreas of rats which are susceptible to alloxan-induced diabetes is significantly lower than in pancreas cells of guinea pigs which are very resistant to diabetogenic action of alloxan (Figure 14). 

Af-Phenylniacinamide, growth-promoting activity of, VII, 116 Phenylpyruvic acid, effect of yeast carboxylase on, VII, 98 2-Phenylquinoline-4Tcarboxylic acid, diabetogenic action of alloxan and, VII, 371... 

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