Allergy adrenal steroids

These are probably the commonest type of drug allergy. Reactions may be generalised, but frequently are worst in and around the external area of administration of the drug. The eyelids, lips and face are usually most affected. They are usually accompanied by itching. Oedema of the larynx is rare but may be fatal. They respond to adrenaline (epinephrine) (i.m. if urgent), ephedrine, Hj-receptor antihistamine and adrenal steroid. 

Marginal blepharitis (various organisms) Oiintnent containing adrenal steroid and an antimicrobial. Undue persistence can be due to allergy to treatment. 

Nguyen KL, Lauver D, Kim I, Aresery M. The effect of a steroid burst and long-term, inhaled fluticasone propionate on adrenal reserve. Ann Allergy Asthma Immunol 2003 91 38-43. 

Zimmerman B, Gold M, Wherrett D, Hanna AK. Adrenal suppression in two patients with asthma treated with low doses of the inhaled steroid fluticasone propionate. J Allergy Clin Immunol 1998 101(3) 425-6. 

Occasional development of Probable development of some adrenal adrenal suppression suppression Aggravation of a dendritic ulcer Discomfort with injection White residue possible Occasional white material, which is Epithelial keratopathy from cosmetically objectionable frequent applications Subconjunctival adhesions Occasional conjunctival infections Allergy to diluent Occasional orbital infection Occasional intraocular injection of steroid Ulceration of conjunctiva after repeated injections if not given behind the eye Exophthalmos and rugae in fundus Papilledema Adrenal suppression Occurrence of systemic side effects more likely... 

Corticosteroid medications are used to treat rheumatoid artiiritis, lupus, asthma, allergies and many other conditions. They also treat situations such Addison disease in which tire adrenal glands do not produce enough steroids, and help prevent organ rejection in transplant recipients. 

Kaufman, H., Bruderman, 1., Gilbard, C. and Schey, G. (1976) Evaluation of pituitary-adrenal function in patients with chronic bronchial asthma following substitution of steroid treatment with disodium cromoglycate (Lomudal). J. Allergy din. Immunol, 57, 267. 

---