Alkynylarenes by Vinylation of Triple Bonds

Vinylation of the triple bond is used industrially for the synthesis of Terbinafin, an anticholesterol drug possessing selective inhibiting activity on squalene 

According to the procedure described in a patent [S. Nakagawa, A. Asai, S. Kuroyanagi, M. Ishihara, Y. Tanaka, US Patent 5 231 183 (1993), to Banyu Pharmaceutical Co.] the final step in the synthesis is carried out by reacting ii-N-(3-chloroprop-2-enyl)-N-methyl-l-naphthalenemethanamine with tert-butylacetylene at 20°C under the conditions shown in Equation 17. 

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