1-Alkynes from dichloromethyllithium

Villieras and coworkers have contributed a considerable number of synthetic methods employing lithium halocarbenoids. An early example was the alkylation of dibromomethyllithium and higher homologs (Scheme 15). The anion (15) is easily generated from 1,1-dibromoalkanes by deprotonation with LDA in THF at low temperature. Alkenes can then be generated simply by treating the products with Bu"Li in EtjO, Alkylation of dichloromethyllithium with primary alkyl halides followed by reaction of the dichloroalkanes with Bu"Li represents a method for the preparation of 1 -alkynes. ... 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

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