4-Alkylthio-7-nitro

Reaction with -alkylthio nitro olefins. Nitro alkenes bearing an alkylthio or phenylsulfonyl group at the -position undergo addition-elimination reactions with organocopper/zinc reagents to provide functionalized (E)-nitro alkenes. 

Scheme 12. R R, R = H, alkyl, aryl, alkylamino, alkylthio, nitro, cyano, alkylsulfonyl,...

Purines, N-alkyl-N-phenyl-synthesis, 5, 576 Purines, alkylthio-hydrolysis, 5, 560 Mannich reaction, 5, 536 Michael addition reactions, 5, 536 Purines, S-alkylthio-hydrolysis, 5, 560 Purines, amino-alkylation, 5, 530, 551 IR spectra, 5, 518 reactions, 5, 551-553 with diazonium ions, 5, 538 reduction, 5, 541 UV spectra, 5, 517 Purines, N-amino-synthesis, 5, 595 Purines, aminohydroxy-hydrogenation, 5, 555 reactions, 5, 555 Purines, aminooxo-reactions, 5, 557 thiation, 5, 557 Purines, bromo-synthesis, 5, 557 Purines, chloro-synthesis, 5, 573 Purines, cyano-reactions, 5, 550 Purines, dialkoxy-rearrangement, 5, 558 Purines, diazoreactions, 5, 96 Purines, dioxo-alkylation, 5, 532 Purines, N-glycosyl-, 5, 536 Purines, halo-N-alkylation, 5, 529 hydrogenolysis, 5, 562 reactions, 5, 561-562, 564 with alkoxides, 5, 563 synthesis, 5, 556 Purines, hydrazino-reactions, 5, 553 Purines, hydroxyamino-reactions, 5, 556 Purines, 8-lithiotrimethylsilyl-nucleosides alkylation, 5, 537 Purines, N-methyl-magnetic circular dichroism, 5, 523 Purines, methylthio-bromination, 5, 559 Purines, nitro-reactions, 5, 550, 551 Purines, oxo-alkylation, 5, 532 amination, 5, 557 dipole moments, 5, 522 H NMR, 5, 512 pJfa, 5, 524 reactions, 5, 556-557 with diazonium ions, 5, 538 reduction, 5, 541 thiation, 5, 557 Purines, oxohydro-IR spectra, 5, 518 Purines, selenoxo-synthesis, 5, 597 Purines, thio-acylation, 5, 559 alkylation, 5, 559 Purines, thioxo-acetylation, 5, 559... 

Alkylthio-imidazole werden bereits durch verdunnte Salpetersaure zu 2-Alkylthio-4(5)-nitro-imidazolen nitriert611 613, wobei manchmal auch die Alkylthio-Gruppe zum Sulfoxid oxidiert wird613. 

Haufig verwendet wird die Oxidation der 4- bzw. 5-Alkylthio- oder Arylthio-Verbindungen von 5- bzw. 4-Nitro-imidazolen1061"1063 mit Wasserstoffperoxid in Essigsaure zu den entspre-chenden Sulfonen, da diese Verbindungsklasse auf dem Wirkstoffsektor von Interesse ist. 

Alkylthio-methyl)-l-nitro-benzole und l-(4-Nitro-benzyl)-pyridinium-Salze reagieren mit Alkalimetallhydroxiden unter Oxidation des benzylischen C-Atoms und Bildung von Azoxy-Verbindungen6 ... 

Although 3-amino-l,2,4-thiadiazoles (e.g. the 5-phenyl homolog) fail to yield nitrosamines under the usual conditions,126 5-nitrosamines are well known.81, 5,190,191 Thus, 3-alkoxy-,8 3-alkylthio-,85 3-dialkyl-amino-,87 and 3-alkylsulfonyl-5-amino-86 (243) as well as 3-aryl-5-arylamino-l,2,4-thiadiazoles,74 on treatment with the calculated quantity of sodium nitrite in dilute mineral acid, or concentrated formic acid, yield crystalline nitrosamines (244). Their unusual stability has permitted a close study of their formation and properties. 170 Their positive Liebermann reaction85,87,170 and the results of their methylation (outlined in the reaction scheme) show that nitro-sation occurs in the side-chain and not in the nucleus.170... 

Many carbanionic nucleophiles that would be considered too hard to react as Michael donors can be made into effective reagents for conjugate addition reactions by appending resonance or inductively stabilizing groups to soften their intrinsic Lewis basicity. Such stabilized anionic Michael donors include enolates, alkylthio-substituted carbanions, ylides and nitro-substituted carbanions. 

The fragmentation of isomeric 5- and 6-nitro-l-/Molucncsulfonyl-2-alkylbenzimida-zoles[695,710],S- 5(6)-nitrobenzimidazol-2-ylmethyl iV-morpholino-dithiocarbamate [1090], 4-, 5-, and 6-nitro-l-[)-A)-ribofuranosyl benzimidazole 3, 5 -phosphates [711], and the products of alkylation of 5(6)- and 4(7)-nitrobenzimidazole derivatives [702] has been studied. The molecular ion peaks of 2-alkylthio- and 2-ethylsulfono-5(6)-nitrobenzimidazole are reported [718],... 

Alkylthio-2-nitro-l-phenyl- E21e, 5020 (En - H/SR) 2-(2-Amino-aryl)-l, 1 -dimethoxy-E6b/1, 569 (N02 NH2)... 

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