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Alkylphosphates, acetylcholinesterase

Wilson, I.B., and Glnsburg, S. A powerful reactivator of alkylphosphate-inhibited acetylcholinesterase. Blochlm. Blophys. Acta. 18 168-170, 1955. [Pg.46]

Wilson, I.B., and Ginsburg, S. Reactivation of acetylcholinesterase inhibited by alkylphosphates. Arch. Biochem. 54 569-571, 1955. [Pg.342]

The basic reaction believed to occur in the inhibition of acetylcholinesterase by some alkylphosphates Is shown in Reaction 1. [Pg.346]

Figure 1. Reaction of soman (GD) with acetylcholinesterase (AChE). (a) Soman and the active site of AChE shown together but not having undergone any reaction, (b) Soman combined with AChE to form an inhibitor-enzyme intermediate, (c) The leaving group (fluoride) has been lost, leaving a complex of soman with AChE. (d) The ester link in the phosphonylated AChE has been hydrolyzed, the enzyme has reactivated and an alkylphosphate has been formed, (e) The link between the large pinacolyl group and phosphorus has been cleaved with the formation of a stable monoalkylphosphonylated complex with AChE and pinacolyl alcohol. The process is known as ageing . Figure 1. Reaction of soman (GD) with acetylcholinesterase (AChE). (a) Soman and the active site of AChE shown together but not having undergone any reaction, (b) Soman combined with AChE to form an inhibitor-enzyme intermediate, (c) The leaving group (fluoride) has been lost, leaving a complex of soman with AChE. (d) The ester link in the phosphonylated AChE has been hydrolyzed, the enzyme has reactivated and an alkylphosphate has been formed, (e) The link between the large pinacolyl group and phosphorus has been cleaved with the formation of a stable monoalkylphosphonylated complex with AChE and pinacolyl alcohol. The process is known as ageing .
See other pages where Alkylphosphates, acetylcholinesterase is mentioned: [Pg.342]    [Pg.211]    [Pg.109]    [Pg.64]   


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