Alkylphenols introduction

Fluorocyclohexadienones. Oxidation of 4-alkylphenols in the presence of HF-pyridine leads to the introduction of a fluorine atom to C-4. The yields are moderate (6 examples, 42-77%). 

As a result of the high reactivity of phenol, alkylation takes place with olefins and alcohols under relatively mild conditions. Methylphenols, i.e. o-, m- and p-cresol, can be produced as a mixture by the alkylation of phenol with methanol. Since reactivity is increased by the introduction of the methyl group, alkylation of cresols to produce xylenols occurs under even milder reaction conditions. The long-chain alkylphenols are also produced by alkylation of phenol. 

MAJOR ALKYLPHENOLS USED IN SURFACTANT APPLICATIONS 3.3.1 Introduction... 

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