Alkylidene-y-and 8-Lactams

Recent Advances in the Synthesis ofoe-Alkylidene-y- and 8-Lactones and Lactams 

In recent years, the growing interest in the biological activities of a-alkyHdene-y and 8-lactones and lactams has resulted in the development of many new and improved synthetic approaches. Because of the vastness of hterature dedicated to this subject, its full coverage was not possible in this chapter. Therefore, 

Cyclization of 2-Alkylidene-4-(5-)Hydroxyalkanoates and 2-Alkylidene-4-(5-) Aminoalkanoates in the Synthesis of a-Alkylidene-y- and 8-Lactones and Lactams 

Retrosynthetic analysis indicates that the simplest, direct precursors of a-alkylidene-y- and 8-Iactones and lactams 20a,b are the corresponding 2-alkylidene-4-(5-) 

1 Organometallic Reagents Derived from 2-Bromomethylacrylic Acid and Its Derivatives in the Synthesis of2-Alkylidene-4-Hydroxyalkanoates and 2-Alkylidene-4-Aminoalkanoates 

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