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Alkylation and The Hofmann Elimination

This is a nucleophilic substitution reaction with the amine acting as a nucleophile. [Pg.72]

The elimination of a quarternsry ammonium salt usually follows an E2 mechanism requiring a strong base. The quaternary alkyl halide, typically an ammonium iodide, is converted to a quaternary ammonium hydroxide using silver oxide. [Pg.72]

Heating the quarternary ammonium hydroxide results in the Hofmann elimination to form an alkene. [Pg.72]

Notice that the LEAST stable alkene is the major product in the Hofmann elimination, called the Hofmann product. [Pg.72]


See other pages where Alkylation and The Hofmann Elimination is mentioned: [Pg.72]   


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Alkyl elimination

Elimination alkylative

Hofmann elimination

The Hofmann Elimination

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