1-Alkylated isoquinoline heterocycles formation

The NMR data which also include /nx couplings have been collected by Pazderski for 105 complexes of Pd(II), Pt(II), Au(III), Co(III), Rh(III), Ir(III), Pd(IV) as well as Pt(IV) complexes with simple azines such as pyridine, 2,2 -bipyridine, 1,10-phenanthroline, quinoline, isoquinoline, 2,2 -biquinoline, l,2 6,2 -terpyridine and their alkyl or aryl derivatives. A short review on the formation and structure of heterocycles obtained from condensation of trifluoromethanesulphonamide with different carbonyl compounds has been written by Shainyan and Meshcheryakov. It contains NMR data including proton-proton couplings. A brief review (in Chinese) on NMR has been written by Li et al ... 

In a similar way, iminoalkynes containing aryl, alkenyl, and alkyl substituents undergoes Cul-catalyzed cyclization in excellent yields and short reaction times to give isoquinolines, pyridines, and pyrroles via a cycloisomerization (eq 18)4 Copper chloride is preferred, however, for the conversion of cyclic alkynyl imines to pyrrole-containing heterocycles. Copper iodide catalyzes the formation of furans from alkynyl ketones. ... 

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