Alkoxy-p-Arylpropionic Acids

Another group of dual hPPARa/y agonists is represented by a-alkoxy-(3-aryIpro-pionic acids, with the general formulae I-IV [6, 7]. 

The first three structural classes are characterized by a polycondensed aromatic ring, the fourth by an ortho, ort/io -disubstituted phenyl ring, and all four classes by a flexible linker between the 2-phenyloxazole and the 0-atom in the para-position to the propionic acid unit. 

A highly simplified model, common to the structures I-IV, is presented in Fig. 3.2. Importantly, the authors concluded that the linkers can be branched due to the Y-shape of the LED in PPARs. This model led to a large number of highly 

Another example of dual PPARo/y agonists, namely, compounds with the general formula V, for which enantiomers with inverse spatial orientation demonstrated improved potency, is shown in Fig. 3.5. 

---