2-Alkenals, oxidative stress

Alkanoyl peracids, crystal stmcture, 125-6 2-Alkenals, oxidative stress, 613 Alkenes... 

Shoute LCT, Alfassi ZB, Neta P, Eluie RE (1994) Rate constants for reactions of (perhaloalkyl)peroxyl radicals with alkenes in methanol. J Phys Chem 98 5701-5704 Sies H (1986) Biochemie des oxidativen Stress. Angew Chem 98 1061-1075 Sies H (1991) Oxidative stress - oxidants and antioxidants. Academic Press, London Simic MG, Jovanovic SV, Niki E (1992) Mechanisms of lipid oxidative processes and their inhibition. ACS Symp Ser 500 14-32... 

The nitric oxide/peroxynitrite mechanism proposed for chemical sensitization illnesses 23,46 dictates that chemicals that lead to oxidative stress in the body would exacerbate the effects by increasing nitric oxide and peroxynitrite concentrations. Many of the chemicals listed in Table 26.4 as well as other heavy metals, polyaromatic hydrocarbons, haloalkanes, aromatic amines, phenols, alkenes, alcohols, and other compounds lead to increased nitric oxide and peroxynitrite concentrations. 77-81 Table 26.5 contains a partial list of these chemicals. 

The rate constants for oxidation of alkanes and alkenes with peroxynitrous acid in aqueous-gas phase are bell-shaped functions of the volume ratio between the liquid and gas phases. The kinetics of the generation of OH radicals and its importance in understanding the mechanism of lipid membrane oxidation has been stressed.236... 

McMahon, M., Lament, D.J., Beattie, K.A., and Hayes, J.D. 2010. Keapl perceives stress via three sensors for the endogenous signahng molecules nitric oxide, zinc, and alkenals. Proc. Natl. Acad. Sri. USA 107, 18838-18843. 

Components of oxidized fats and oils may also accelerate the turnover of vitamin E and increase the susceptibility of the red cells to hemolytic stress. Alkenal, hydroxylalkenal and hydroperoxyalkenal, for example, have been shown to be more potent than methyl linoleate hydroperoxide in inducing hemolysis (Yoshioka and Kaneda, 1972, 1974). 

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