Alkanes aminomethylation

Added CO2 allows the synthesis of substituted maleic anhydrides. According to a novel aminomethylation, ethane or propane is reacted with /V./V-di alkyl methyl-amine A-oxides in the presence of trifluoroacetic acid and a catalytic amount of Cu(OAc)2 to afford A,A-dialkylaminomethylated alkanes in good yields 321 337 338... 

Exploitation of Synthetic Reactions Via C—H Bond. Activation by Transition Metal Catalysts. Car-boxylation and Aminomethylation of Alkanes or Arenes. 

In relation to the three-component indole formation, a novel four-component synthesis of 3-(aminomethyl)isoquinoline was developed. The reaction of 2-ethynylbenzaldehyde with (HCHO) , secondary amine, and t-BuNH2 proceeds through Mannich-type reaction, cycUzation, and elimination of t-butyl group. By the use of alkane diamine instead of r-BuNH2, 3-(aminomethyl)isoquino-line-fused polycyclic compounds were also synthesized by cascade cycUzation and oxidation. Changing the carbon tether of the diamine component led to the synthesis of isoquinoUnes fused with various heterocycles. 

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