Alkaloids of Haplophyllum Species

Part of plant Alkaloids found Physical properties li(4er(Tiee  

Haplophyllidine is a strong depressant of the central nervous system it synergizes the effects of hypnotic drugs in mice, rats, and rabbits, and antagonizes the action of analeptics (145). 

Dubinine has been identified as the monoacetyl derivative LXXX of dubinidine, to which it is hydrolyzed by hot 5% hydrochloric acid (149). 

The underground parts of H. foliosum contain khaplofoline, C14H15NO2, an optically inactive alkaloid which is oxidized by permanganate to iV-oxalylanthranilic acid chromic acid oxidation gives acetone and 0.7 mole of acetic acid. Its UV-absorption is that of a 4-quinolone and treatment with methyl iodide and potassium carbonate in acetone produces an iV -methyl derivative acetylation gives iV-acetyl-khaplofoline. The structure LXXXIII proposed for the alkaloid (142) 

The root and bark of the Hawaiian shrub Platydesma campanulata Mann contain evolitrine, kokusaginine, and the new alkaloids 1,2-dimethyl-4-quinolone (XI) (Section II), 6-methoxydictamnine (Section III,A,2), and platydesmine the leaves contain kokusaginine, 1,2-dimethyl-4-quinolone, and the new alkaloid pilokeanine 29). 

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