Alkaloids Cryptolepis sanguinolenta

Homocryptolepinone 426 (Figure 10) was isolated from the extracts of the indigenous Ghanaian medicinal plant Cryptolepis sanguinolenta (1995JHC1631), as well as the alkaloid cryptoheptine 427 that was identified in other related... 

There were a several additional studies of members of the indoloquinoline family of alkaloids isolated from Cryptolepis sanguinolenta reported that utilized 3 mm micro-NMR probe capabilities reported in 1995. The elucidation of the structure of quindolinone (16) was reported next and also utilized 3 mm micro-probe technology for the acquisition of a HMQC spectrum on an 800 pg sample of the... 

The root of the plant Cryptolepis sanguinolenta (Lindl.) Schlt (Periplocaceae) is used in traditional African medicine to treat a variety of diseases including malaria, jaundice, hepatitis, urinary tract infections, hypertension, inflammatory conditions and stomach ache. Extracts of the roots are also used as a tonic often taken daily for years without evidence of toxicity. Various studies indicate that the crude extracts as well as the isolated alkaloidal constituents of the plant possess a number of interesting pharmacological properties. The focus of this overview is to highlight the potential of Cryptolepis sanguinolenta in modem health care. 

Tackie, A., Schiff, P., Sharaf, M. Antimalarial alkaloids from Cryptolepis sanguinolenta. WO9418203. PCT Int. Appl. (1994). 

More recently Wright analyzed the bioactive possibilities of cr3qjtolep-tine, the main alkaloid from Cryptolepis sanguinolenta, as an antimalarial agent. The bioactivity of alkaloids against parasites is becoming... 

Ablordeppy SY, Hufford CD, Bourne RF, Dwuma-Badu D (1990) Proton NMR and carbon-13 NMR assignments of cryptolepine, a 3 4-benzo-d-carboline derivative isolated from Cryptolepis sanguinolenta. Planta Med 56 416-417 Alam M, Mroue M (1991) Crooksiine, a bisindole alkaloid from Haplophyton crooksii. Phytochemistry 30 1741-1744... 

Struct, unknown. Mol. formula not reported. Co-occurs with Cryptolepine and Quindoline (see 10/f-Indolo[3,2-6]quinoline, 1-00134). Could possibly be identical with the recently isolated Isocryptolepine. Alkaloid from roots of Cryptolepis sanguinolenta (Asclepiadaceae). Mp >300°. 

Recently a complement-modulatory activity has been reported for a series of alkaloids isolated from Cryptolepis sanguinolenta (Lindl.) Schlechter (Periplocaceae). The monomeric alkaloids cryptolepine (tested as its hydrochloride) (62), quindoline (63), and hydroxycryptolepine (64) exhibited a dose-dependent inhibitory effect on the classical pathway [38]. The activity (% inhibition) at a concentration of 1 mM... 

Table 6 - Inhibition of the classical pathway (CP) and the alternative pathway (AP) of the complement system by alkaloids from Cryptolepis sanguinolenta (62-65) reduction of haemolysis (%) at a concentration of 1 mM [38].

Cimanga K, De Bruyne T, Van Poel B, Pieters L, Claeys M, Vanden Berghe D, Vlietinck A (1997) Dimeric alkaloids from Cryptolepis sanguinolenta as potent inhibitors of complement pathway activation. Pharm Pharmacol Lett 7 179-180... 

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