Toxic aleukia, alimentary , human

Severe disease known as alimentary toxic aleukia (ATA) occurred in humans who had eaten overwintered... [Pg.360]

The toxic effects of mycotoxins in humans have been reviewed by Peraica (Peraica et al, 1999). Toxins produced by F. sporotrichioides, with T-2 toxin believed to be the principal toxin, were implicated with the human disease alimentary toxic aleukia (ATA). Alimentary toxic aleukia was recognized prior to 1900 in the USSR, with thousands of people developing ATA and many dying after consuming cereals that overwintered in fields during and after World War II. [Pg.364]

Chronic exposure to subacute doses of trichothecene mycotoxins is not thought to be an effect of biological warfare. This type of exposure, however, was responsible for ATA toxicosis in humans and mycotoxicosis in domestic animals. In addition, chronic toxicity has been iatrogenically induced when repeated subacute doses of a trichothecene mycotoxin were administrated intravenously to cancer patients as a chemotherapy for colon adenocarcinoma. Alimentary Toxic Aleukia Toxicosis... [Pg.667]

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