Rifampicin Alfentanil

OPIOIDS RIFAMPICIN 1 effect of alfentanil, codeine, methadone and morphine Rifampicin t hepatic metabolism of these opioids (alfentanil by CYP3A4, codeine by CYP2D6, morphine unknown). Rifampicin is also known to induce intestinal P-gp, which may 1 bioavailability of oral morphine Be aware that alfentanil, codeine, methadone and morphine doses may need to be t... 

The serum levels and effects of transdermal fentanyl were decreased when one patient took rifampicin. Studies in healthy subjects have shown that the bioavailability of transmucosal fen-tanyi is reduced, and the clearance of intravenous alfentanil is markedly increased, by rifampicin. 

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