Aldolase-catalyzed stereocontrolle

Aldolase-catalyzed stereocontrolled aldol condensation is getting increasing acceptance in modem research and production as an alternative to classical chemical methodology [21-23]. The potential of enzymes as catalysts for the synthesis of carbohydrates has been also deeply explored [23-29],... 

H.l. Lamble, M.l. Danson, D.W. Hough, S.D. Bull, Engineering stereocontrol into an aldolase-catalyzed reaction, Chem. Commun. Ian (2005) 124-126. 

One of the most classical reactions for the formation of C-C bonds is the aldolic condensation. In nature, such stereocontrolled reactions are catalyzed by enzymes of the class of lyases (EC 4). The majority of these enzymes can be found in the biosynthesis of carbohydrates, and are used for the synthesis of natural and unnatural carbohydrates. Aldolases (and transketolases) have been intensively investigated and their scope of applications has been evaluated and reviewed by the groups of Whitesides and Wong [16, 21,142-145] (see also Chapter B4 in [22]). Aldolases can be divided into three main types ... 

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