Aldol Reactions via Activation of Silyl Enolates

Eluoride ion-catalyzed aldol reactions of silyl enolates are valuable for stereoselective carbon-carbon bond formation [19]. In this system fluoride ion works as an activator of silyl enolates to produce reactive metal-free enolates, which add to aldehydes as the actual nucleophiles. Similar aldol reactions via activation of silyl enolates by nucleophilic reagents and solvents have been reported in recent years. In addition, activation of silyl enolates by transmetalation has attracted much attention because of its possible application to diastereo- and enantioselective transformation. 

TMS enolates are well known to react with some metal compounds to afford the 

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