Aldol reaction catalyzed by various metal salts

2 Aldol reaction catalyzed by various metal salts 

Although the element scandium is in group 3 and lies above La and Y, its use in organic synthesis is rather limited in spite of its promising properties. In the course of our investigations to search for novel Lewis acid catalysts, especially metal triflates, we focused on the element scandium. 

Sc(OTf)3 was found to behave as a Lewis acid catalyst in aqueous media [21]. Sc(OTf)3 was stable in water and was effective in the aldol reactions of aldehydes 

Entry Aldehyde Silyl enol ether Yield% 

14 Activation of Carbonyl and Related Compounds in Aqueous Media 

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